Services

Capability Overview

DHMRI Services Inc. is your trusted CRO partner focused on human health, nutrition & agriculture, delivering high-quality services for:

  • Genomics

  • Metabolomics

  • NMR

  • Bioinformatics

We support you with:

  • An expert multi-disciplinary team
  • Multi-platform solutions
  • Sample generation to data delivery
  • Capability & capacity to support all your research

Genomics

Our comprehensive Genomics offering includes:

Genome assembly:

  • De novo or reference genome sequencing using short, long, and linked-reads
  • Exome sequencing

Genetic Analysis via sequencing and array platforms:

  • Indel characterization
  • Off-target mutation screening
  • Haplotype profiling

Microbiome Studies:

  • Metagenomic analysis of complex microbe populations

Transcription Profiling:

  • Bulk RNA-Seq
  • 3’ RNA-Seq
  • Single cell Drop-Seq profiles

Epigenetic Characterization via sequencing and array platforms:

  • DNA methylation
  • Single cell chromatin profiling

Metabolomics

Our comprehensive Metabolomics offering includes:

Discovery panel:

  • Identification & quantitation of a range of metabolic pathways

Targeted Quantitative Assays:

  • Targeted profiling of specific pathways or metabolites

Custom Assays:

  • Quantitative measurement of metabolites in a wide variety of matrices

Structural Elucidation:

  • Unmatched ultra-high field NMR for determining structures of unknowns

NMR

Use our world-leading NMR facility and expertise to access critical structural and dynamic information on important biological systems and medically relevant targets. We support you with:

Multiple Nuclear Magnetic Resonance instruments:

  • 400MHz, 600MHz, 700MHz
  • Ultra-high field 950MHz – one of only a few in the USA and only CRO available instrument
  • Cryogenically cooled probes for increased sensitivity

Multiple applications across all life sciences:

  • Characterization and quantitation of small molecules and proteins
  • Structural elucidation
  • Inherent quantitation

Fast turnaround

A highly experienced team

Additional analytical instrumentation for:

  • Liquid Chromatography-Mass Spectrometry (LC-MS)
  • Gas Chromatography-Mass Spectrometry (GC-MS)
  • Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Bioinformatics

Our dedicated bioinformatics team employs a broad range of analytical tools and expertise to acquire, manage, integrate, and optimize disparate data for Genomics, Proteomics, Metabolomics, and in vitro studies.

A selection of services by application area includes:

Genomics:

  • Advanced Sequencing QC Analysis
  • Reference mapping/alignments
  • Variant Calling (SNV/SNP)
  • Structural Variation Detection (indels, inversions, CNV, etc.)
  • De novo genomic assembly, finishing, and annotation
  • Metagenomic assembly
  • Transcriptomics
    • Novel splicing sites, exon, and transcript discovery
    • RNASeq and Differential Expression Analysis (microarray data as well)
    • Small RNA analysis
    • De novo assembly
    • RNA secondary structure prediction
  • Pathway analysis
  • Targeted Resequencing Analysis
  • Bis-DNA and methylated DNA sequencing analysis
  • ChIP-Seq analysis
  • Phylogenetics
  • BLAST/database querying and analysis
  • Genome Wide Association Studies (GWAS)

Proteomics:

  • Expression profiling
  • Pathway analysis
  • BLAST/database querying and analysis
  • Pattern discovery
  • Motif discovery
  • Signal peptide discovery
  • Secondary structural determination and prediction
  • Clustering

Metabolomics

  • Pathway analysis
  • Data annotation
  • Multivariate analysis
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